肝内胆管癌精准检测专家共识（2024版）

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摘要：肝内胆管癌（ICC）是一种高度异质性的肿瘤，分子分型是实施ICC个体化治疗的基础。正确的检测方法对于全面筛选适用靶向药物的患者群体具有重要的临床意义。本共识基于国内外临床实践数据，并结合中国国情，围绕ICC重要靶点进行制定，提出了15条推荐意见，以期为ICC的精准检测提供参考。

关键词：肝内胆管癌；精准检测；生物标志物；个体化治疗

基金项目：上海市科学技术委员会项目（22JC1403002）

Expert consensus on precision detection of intrahepatic cholangiocarcinoma （2024 edition）

Pathology Group，Chinese Society of Liver Cancer of Chinese Anti-Cancer Association；Liver Pathology Group，Chinese Society of Pathology of Chinese Anti-Cancer Association；Tumor Pathology Committee of Shanghai Anti-Cancer Association，Shanghai200032，China

Corresponding authors：LI Zengshan，Zengshanli@qq.com；CONG Wenming，wmcong@smmu.edu.cn；JI Yuan，ji.yuan@zs-hospital.sh.cn

Abstract：Intrahepatic cholangiocarcinoma （ICC） is a highly heterogeneous tumor，and molecular profiling serves as the foundation for personalized treatment of ICC. Accurate detection methods are clinically significant for comprehensively screening patients suitable for targeted therapies. This consensus is based on clinical practice data from both domestic and international sources，tailored to the Chinese context，and focuses on key targets for ICC. We present 15 recommendations aimed at guiding the precision detection of ICC.

Key words：Intrahepatic Cholangiocarcinoma；Precision Detection；Biomarkers；Personalized Treatment

Research funding：Science and Technology Commission of Shanghai Municipality （22JC1403002）

肝内胆管癌（intrahepatic cholangiocarcinoma，ICC）是一种高度侵袭性肝内胆管上皮性肿瘤，占肝脏原发恶性肿瘤的8.2%～15.0%，仅次于肝细胞癌［1-2］。（剩余15591字）