门静脉血栓动物模型的建立和应用

摘要： 门静脉血栓（PVT）是指在肝外门静脉主干和/或肝内门静脉分支内发生的血栓栓塞。PVT是由多种因素共同作用的结果，但其发病机制尚未完全阐明。建立动物模型是研究PVT病理生理机制的重要方法。本文根据不同的动物种类，对现有PVT动物模型的建立方法、原理、优缺点和应用情况进行综述。

关键词： 门静脉血栓； 疾病模型， 动物； 发病机制

Establishment and application of animal models for portal vein thrombosis

Abstract： Portal vein thrombosis （PVT） refers to thromboembolism that occurs in the extrahepatic main portal vein and/or intrahepatic portal vein branches. PVT is the result of the combined effect of multiple factors， but its pathogenesis remains unclear. Animal models are an important method for exploring the pathophysiological mechanism of PVT. Based on the different species of animals， this article reviews the existing animal models of PVT in terms of modeling methods， principles， advantages and disadvantages， and application.

Key words： Portal Vein Thrombosis； Disease Models， Animal； Pathogenesis

门静脉血栓（portal vein thrombosis，PVT）形成是指在肝外门静脉主干和/或肝内门静脉分支内发生的血栓栓塞［1］。（剩余12307字）