抗菌肽的活性优化及异源表达研究进展

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中图分类号：R945，Q78 文献标志码：A

Progress on the activity optimization and heterologous expression of antimicrobial peptides

ZhangMeilingl2，SongJia²， Sun Bo2 ，Yan Xue， Zhao Chen²，and Zhang Wanzhong1 （1 College ofEnvironmentalandSafetyEnginering，Shenyang Universityof ChemicalTechnology，Shenyang10142; 2 AcademyofNationalFoodandStrategicReserves Administration，Beijing 10oo37;3NewHopeLiuheLimitedCompany/Key Laboratory ofQualityControl forFeedand Products ofLivestockand Poultry of Sichuan Province，Chengdu 610023）

AbstractAntimicrobial peptides （AMPs） are a class of polypeptides with antimicrobial activity. Compared with traditional antibiotics，AMPs have broad-spectrumantibacterialactivityand can overcome the drug resistance of pathogenic microorganisms，so they have become the hotspot of “antibiotic alternatives”research. Although antimicrobial peptidesare promising inthefelds of medicine，lifescience，and feed industry，many problems stil remain，suchas high acquisitioncost，short half-life，andthegapin minimum inhibitoryconcentrations compared to antibiotics，etc.，which limittheir furtherdevelopment andapplication.Therefore，the studyontheoptimizationof the AMPs acquisition method and the improvement of biological activities is necessry. In this review，the structure types and biologicalactivitiesof the AMPs were briefly introduced，the activity optimization and heterologous expression of antimicrobial peptides were extensivelysummarized，and the future of their industrialization was also prospected in order to provide references for the development and application of antimicrobial peptides.

Key wordsAntibacterial peptides; Biological activity; Structure optimization; Heterologous expression

抗生素耐药性问题已成为全球主要的公共卫生威胁之一，因此迫切需要创新型抗生素替代产品。（剩余18406字）