中药通过影响翻译后修饰过程防治结直肠癌的探讨

关键词：结直肠癌；翻译后修饰；中药；黄连；吴茱萸；黄芩；泛素化；类泛素化；乙酰化中图分类号：R273.53 文献标志码：A 文章编号：1007-3213（2025)02-0505-07DOI:10.13359/j. cnki.gzxbtcm.2025.02.036

Exploration of Chinese Herbal Medicines in the Prevention and Treatment of Colorectal Cancer by Influencing the Post-Translational Modification Process

LIANG Yingying，JIA Zhen，FU Wanting，LU Linlin (ScholofPharmaceuticalSciences，Guangzhou UniversityofChinese Medicine，Guangzhou51oo06Guangdong，China）

Abstract:In recent years，the post-translational modification inepigenetics has drawn theattention of the researchers，and is expected to become the important direction for tumor pharmacology research in future.Chinese herbal medicine has the advantages of less side effects and better efficacy，and has shown good prospects in the research of prevention and treatment of colorectal cancer.This paper outlined the types of post-translational modifications in epigeneticsand their roles in the progresson of colorectal cancer，and explored the possible mechanisms of single Chinese herbal medicine and Chinese herbal compounds in the treatment of colorectal cancer byinfluencing post-translational modifications.In the progresion of colorectal cancer，the post-translational modifications suchasubiquitination，ubiquitination-like，acetylation，crotonylationand glycylationwere involved.The Chinese medicinal active ingredients from Coptidis Rhizoma，Euodiae Fructus，Scutellriae Radix, Curcumae Longae Rhizoma，etc.，and Chinese herbal compounds of Yiliu Decoction and Teng Long Buzhong Decoction have allshown certain efects forthe prevention and treatment of colorectal cancer byparticipating in post-translational modifications.The in-depth exploration of the therapeutic mechanism of Chinese herbal medicine in the prevention and treatment of colorectal cancer and the development of new Chinese medicinal preparations from the perspective of post-translational modification are expected to becomea new direction for the future research on the mechanism of anti-colorectal cancer and on the application of anti-cancer agents.

Keywords:colorectal cancer；post-translational modification；Chinese herbal medicine；Coptidis Rhizoma; Euodiae Fructus；Scutellariae Radix；ubiquitination；ubiquitination-like；acetylation

结直肠癌为消化系统的常见肿瘤之一，其发生率近年来逐渐上升1。（剩余15395字）