超声引导下射频消融术在小肝癌临床治疗中的可行性研究

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Feasibility study of ultrasound-guided radiofrequency ablation in the clinical treatment of small liver cancer Wang Jin，Cui Haixia，Yan Binghui.Department of Ultrasound Medicine，Sanmenxia Central Hospital，Henan 472000， China

【Abstract】ObjectiveTo explore the feasibilityof ultrasound-guided radiofrequencyablation （RFA）in the clinical treatment of small hepatocellular carcinoma.MethodsAretrospective studywasconductedon 85 patients withsmall livercancer who weretreated inour hospital from May2O19 toMay2O21.Acording tothedifferencein surgical methods，they were divided into two groups： partial hepatectomy group（ n=40 cases） and RFA group（ n =45 cases）.Theeficacy，rehabilitationindicators，liver function，tumor markersand prognosisof the two groups were compared.ResultsThere was no significant diference in objective response rate（ORR）and disease control rate （DCR） between the two groups（ P- >0.05）.The operation time and hospital stay in the RFA group were shorter than those inthe partial hepatectomy group，andthe amount of intraoperative bleeding was less than that in the partial hepatectomy group （ P <0.05）.After treatment，ALT，AST，and TBIL in the two groups increased，while alpha - fetoprotein （AFP）decreased.ALT，AST，and TBIL intheRFA group were lower than those inthe partial hepatectomy group （ P <0.05），but there was no significant difference between the two groups in AFP（ P >0.05）.The complication rate in the RFA group was 7% ，which was lower than that in the partial hepatectomy group（ 22% ， P<0.05 ）.Therewas no significant difference in the 1-year and 3-year OS rates between the two groups （P>0.05 ）.ConclusionCompared with partial hepatectomy，theshort-term eficacyandlong-term prognosisof ultrasound-guidedRFA inthetreatmentof small hepatocelular carcinoma are similar，but ithas certain advantages in reducing liver functiondamage，facilitating rehabilitation， and reducing complications.

小肝癌是指病灶直径 ≤3cm 的肝癌，以中老年男性为主，在生活节奏加快、饮食结构改变大背景下，小肝癌发病率逐年递升1。（剩余5459字）