肥厚型心肌病的靶向药物研究进展

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【Abstract】Precisiontargetedtherapyisreplacingtraditionalpharmacologicaltreatmentforhypertrophiccardomyopathy.Traditoal medications including β -blockersandnon-diydropyridinecalciumchannelblockerscanlowermyocardialoxygendemand，buttheireffectiveess isimitedBsecallocgyodaloactiotdedcaselysinae greatlyreduceleftventriulautloractorctionadferaevolutoarytreatentptionforsmptoatichyperoicdoathy. Howeveritsotaltaitlaolistlcnodeoatesic andclinicalresearch，thispaper examines theresearchdevelopmentof targetedmedications inhypertrophiccardiomyopathy.

【Keywords】Hypertrophic cardiomyopathy;Genetic mechanism;Targeted drug

肥厚型心肌病（hypertrophiccardiomyopathy，HCM）以左心室肥厚为主要特征，在排除其他可能导致同等程度肥厚的心脏性、系统性或代谢性疾病后，其病因可归因于肌节（或肌节相关）致病基因变异，或尚未完全阐明的遗传机制[1]。（剩余14988字）