肿瘤相关成纤维细胞对恶性肿瘤生物学行为及治疗影响的研究进展

[中图分类号] R329.25;R730.23 [文献标志码] A

Research advances in the effect of cancer-associated fibroblasts on the biological behavior and treatment of malignant tumorsYUN Jie，，BIAN Chao，LI Zhijun（Iner Mongolia Clinical College，Inner Mongolia Medical University，Hohhot Olool0，China）

[ABSTRACT]Tumor microenvironment （TME） plays an important role in the structure and function of malignant tumor stroma.Cancer-associatedfibroblasts（CAFs）haveastrongablityofextracellarmatrixsynthesisandmicroenvironmentremode ling，whichcanafectthedevelopmentand progresionoftumors.CAFscanproducethesubgroups withdiferentfunctionsindifferenttypesofTME，andthestudyofCAFsubgroupshasaguidingsignificancefortumortherapy.Thisarticlereviewstheeffect of CAFsanditssubgroupsonthebiologicalbehaviorand treatmentofmalignanttumors，inordertoprovideareferenceforthe clinical treatment of malignant tumors.

[KEY WORDs]Cancer-asociated fibroblasts；Tumor microenvironment; Extracellular matrix；Molecular targeted therapy; Review

肿瘤的发生发展除受自身基因和表观遗传缺陷影响外，还受肿瘤微环境（TME）调控[1]。（剩余12016字）