鼻咽癌患者放疗后中耳炎、鼻窦炎发生的危险 因素分析

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[中图分类号] R739.6 [文献标志码] A

Risk factors for otitis media and sinusitis in patients with nasopharyngeal carcinoma after radiothera

pyCUI Ziyuan， WANG Lin， ZHANG Jisheng，LI Shunke，YAN Xudong，JIANG Yan（Departmentof Otorhinolaryngology Head and Neck Surgery，The Afiliated Hospital of Qingdao University，Qingdao 266035，China）

[ABSTRACT]ObjectiveToinvestigatetheriskfactors forotitismediaandsinusitisinpatients with nasopharyngeal carcinomaafterradiothe-rapy.MethodsTheclinicaldatafrom2O7patientswith nasopharyngealcarcinoma whounderwentradiotherapyattheAffiatedHospitalofQingdaoUniversitybetweeJanuary2O13andDecember2019werecollected.Theclinical characteristicsof patients whodevelopedotitis mediaand sinusitis afterradiotherapywerecompared withthoseof patients whodid not.Univariateandmultivariatelogisticregresionanalyseswereperformedtoidentifyriskfactorsforpost-radiotherapyotitis mediaandsiusitisAdditionally，thecorrelationbetweetheoccurrenceofotitis mediaandsinusitisafterradiotherapywasanalyzed.ResultsComparisonof 207patients with nasopharyngealcarcinomabeforeandafterradiotherapyshowed statisticalysignificant differences in the severity of otitis media and sinusitis （χ2=12.903-31.373，P<0.05） .Multivariate logistic regression analysis revealed that tumor T stage was a risk factor for post-radiotherapy otitis media （ P<0.05 ，and smoking and tumor T stage were risk factors for post-radiotherapy sinusitis （ P<0.05） . A significant correlation was observed between the occurrence of post-radiotherapy otitis media and sinusitis （ r=0.22，P<0.05 .ConclusionFor patients with nasopharyngeal carcinoma at a highTstageandhavingahistoryofsmoking，closeatentionsouldbepaidtotheoccurrenceofpost-radiotherapyotitis mediaand sinusitis. Early intervention is essential to improve patients’ quality of life.

[KEY WORDs]Nasopharyngeal carcinoma;Radiotherapy，intensity-modulated;Otitis media； Sinusitis；Risk factors

鼻咽癌是头颈部常见的恶性肿瘤，在北非及我国南方等地发病率较高[1-2]。（剩余8502字）