不同潮气量通气对重症肺炎患儿呼吸力学和血流动力学的影响

打开文本图片集

中图分类号：R725.6 文献标志码：A DOI：10.11958/20250327

Study on the effects of different tidal volume ventilation on respiratory mechanics and hemodynamics in children with severe pneumonia

WU Xiaoxial，GUO Jianxin1，QU Mengting1，NADIR Hairula1，ZHAYIDAN Aili1， CHENG Yongfeng2△

1， ， 83oo54， Corresponding Author E -mail： 1456301676@qq.com

Abstract：ObjectiveToinvestigatetheeffctofventilationwithdifferenttidalvolumesonrespiratorymechanicsand haemodynamics inchildren with severe pneumonia.MethodsAtotalof104children with severe pneumonia were divided into the control group and the observation group usingarandom numbertable method，with 52 cases in each group.Both groups underwent mechanical ventilation treatment.Thecontrol group was treated with conventional tidal volumeof 10- 12 mL/kg，while the observation group was given alow tidal volumeof 6-8 mL/kg.Therespiratory mechanics indicators， hemodynamic indicatorsand inflammatory factor indicators before andafter treatment were compared between the two groups.ResultsAfter treatment，theairway resistance （AR）and airwayclosing presure （AOP）were lower in the observation group than those of the control group （ P<0.05 ），and pulmonary dynamic compliance （Cdyn） was higher in the observation group than that of the control group （ P<0.05 ）. There were no significant differences in heart rate （HR），mean arterial pressure （MAP） and central venous pressure（CVP） after treatment between the two groups （ P<0.05 ）.After treatment， the levels of interleukin （IL）-6， IL-8 and tumor necrosis factor- α （TNF -α ）were all lower in the observation group than those in the control group （ P<0.05 ）.ConclusionSmall tidal volume mechanical ventilation is effective in improving the respiratory mechanics of children with severe pneumonia without causing large fluctuations in their hemodynamics.At the same time，it canreduce the level of inflammatory factors in the organism.

KeyWords：tidal volume; respiration，artificial; respiratory mechanics; hemodynamics;severe pneumonia

肺炎是儿科常见疾病，小儿肺部及免疫系统正处于发育阶段，纤毛运动较差，黏液分泌量不足导致微生物、异物等无法有效排出，极易受到感染进而引发肺炎[1]。（剩余9981字）