胰腺癌靶向治疗及免疫治疗的研究新进展

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【中图分类号】R735.9【文献标识码】A DOI：10.12114/j.issn.1007-9572.2024.0195

【Abstract】Pancreaticcancer isa highlymalignant disease withapoor prognosis.Currntly，there isalack of efectiveearlydetectionmethods，resulting inmostpatients beingdiagnosedatanadvanced stageorwithdistantmetastasis. Furthermore，theunique tumor microenvironment poses chalenges for traditional treatment modalities such as surgery， radiotherapy，and chemotherapy.Thisarticleprovidedacomprehensivereviewof thelatestadvancementsinpancreaticcancer treatmentbothdomesticallyandinternationally.Italsosummarizedrelevantiteratureontargetedtherapyandimmunotherapyfor pancreaticcancer.Thearticle highlightedthatcontinuousdevelopments ingenesequencingandmulti-omicsresearchdeepened ourunderstandingof themolecularmechanismsandgeneexpresionprofilesasociated withpancreaticcancer.onsequently， numeroussignalingpathwaysandtargetshadbeenidentifiedalong withanarayoftargetedtherapyandimmunotherapydrugs.As aresult，the treatment approach for pancreatic cancer was graduallyshifting froma conventional "one-size-fits-al χ′′ strategy to morepreciseindividualizedtreatments，usheringinnewpossibilitiesforcombatingthisdisease.Thisstudyoferednovelisights that could guide further research on targeted therapy and immunotherapy for pancreatic cancer

【Key words】 Pancreatic cancer；Tumor microenvironment；Targeted therapy；Immunotherapy；Review

胰腺导管腺癌（pancreatic ductal adenocarcinoma，PDAC）占胰腺癌 90% 以上，是致命的恶性肿瘤之一，也是癌症相关死亡的主要原因之一，其5年生存率仅为 9%[1-2] 。（剩余38331字）