转移性结直肠癌患者味喹替尼治疗相关心血管毒性发生率和风险的Meta分析

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【中图分类号】R735.34【文献标识码】A DOI：10.12114/j.issn.1007-9572.2024.0203

【Abstract】Background38.4%ofpatients withcolorectal cancerdied from non-cancerdisease，withcardiovascular disease being the most important cause，accounting for 20.3% of the total deaths. Cardiovascular toxicity associated with targeted therapyis notuncommon，mostnotably hypertension.ObjectiveThestudyaimedtodeterminetheoverallincidenceandrisk ofcardiovasculartoxicityassociatedwithfruquintinib inmetastaticcolorectal cancer.MethodsWesearchedCNKI，Wanfang Data，CBM，PubMed，Embase，WebofScienceandCochraneLibrarydatabases forsingle-armclinicaltrialsandrandomized controlledtrials（RCTs）relevanttofuquintinibtherapyinpatientswithmetastaticcolorectalcancer.Thesearchtimelimit wasfromtheestablishmentofthedatabases toMay2O24.Literaturescreening，dataextraction，andqualityevaluationwereperformed independentlybytwoinvestigators.The meta-analysis wasconductedusingR4.3.3software.ResultsEightarticles involvingsix single-armclinical trialsand threerandomizedcontroledtrialswere included.The meta-analysisresultsshowedthattheincidence rates of all-grade hypertension and hemorrhage were 35 % （95%CI=0.25-0.45） and 24% （95%CI=0.10-0.37），respectively. For high-grade events，the rates were 15% for hypertension（95%CI=0.10-0.20）， 1% for hemorrhage（95%CI=0-0.02）， （204号 3% for embolic and thrombotic events（95%CI=0.02-0.05），and 1% for cardiac diseases （95%CI=0-0.02）.Fruquintinib was associatedwithincreasedrisksforbthall-gradeandhiggradehypertension，aswellasall-gradehemorhage，withRRf3.93 （95%CI=2.95-5.24），12.33（95%CI=5.31-28.63），and1.84（95%CI=1.36-2.50）respectively，but notforhigh-grade hemorrhage（RR=1.06，95%CI=0.35-3.23），embolicandthrombotic events（RR=3.35，95%CI=0.89-12.55），orcardiac diseases（RR=0.62，95%CI=0.18-2.14）.ConclusionTheuseoffruquintinib issociated withasignificantlyincreasedrisk of developing cardiovasculartoxicity，primarilyforlower-grade events，in patients with metastaticcolorectalcancer.

【Key words】Metastatic colorectal cancer；Fruquintinib；Cardiovascular toxicity；Meta-analysis

结直肠癌是消化道最常见的恶性肿瘤，据2020年发布的全球癌症统计数据，结直肠癌的发病率为 10% 居第三位，死亡率为 9.4% ，居第二位[1]。（剩余13341字）