铜稳态调节机制在认知障碍中的作用探析

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【中图分类号】 R741 【文献标识码】 ADOI：10.12114/j.issn.1007-9572.2024.0200

【Abstract】Cognitive impairment is often manifestedasaseries of brain functiondeficits such as learning，memory， intelectual，emotional，andexecutive deficits.Itoftenoccurs inneurological disorders，aging，andthepostoperative period.Currently，thepathogenesisofthedisease isunclear，andthe blood-brainbarier，oxidative stress，autophagy， inflammation，mitochondria，andneurotransmiters haveallbeenimplicated incognitivedysfunction.Recent studies found thatcopperhomeostasisasociated withcopper metabolismandcopperdeathhadaregulatoryroleincognitivefunction，which maybeakey mechanisminthedevelopmentofcognitiveimpairment.Inthispaper，wesystematicallintroducedtheroleof copperhomeostasisregulatorymechanisms incognitiveimpairmentfromtheperspectivesofmitochondria，glialcels，oxidative reactions，inflammatory factors，neurotransmiters，etc.（Whencopperhomeostasis wasimbalanced，copperionlevels were disturbed，electrolytemetabolismwasbnormal，andasriesofreactions，suchasoxidativestress，inflammatoryaggregation， mitochondrial disorders，and glialcelldamage，ocur，and even induce neuronalcopperdeath）andsummarised theroleof copperhomeostasis incognitiveimpairment.Theroleofcopperhomeostasisincognitivedisorderswassummarised，toprovide newinsightsintothepathogenesisofcognitivedisorders，aswellasbringingnewsolutionstothetreatmentofthedisease.

【Key words 】 Cognitive impairment；Copper steady state；Copper metabolism；Copper death；Review

我国人口老龄化趋势明显上升，预计到2040年，60 岁及以上人口的比例将达到 28%，估计为4.02亿[1]进一步调查显示，痴呆发病率也呈现上升的趋势，全球有近5000万人患有痴呆症，预计到2050年这一数字将增加到1.52亿[2]。（剩余26397字）