代谢相关脂肪性肝病与2型糖尿病共同管理研究进展

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【关键词】代谢相关脂肪性肝病；2型糖尿病；糖肝共管；代谢疾病；慢性肝病 【中图分类号】 R 575.5 R 587.1 【文献标识码】 ADOI：10.12114/j.issn.1007-957.2024.0591

【Abstract】Metabolic dysfunction-associated fatty liver disease（MAFLD）and type 2 diabetes melltus（T2DM） are the wo most common metabolicdiseases worldwide.Thecoexistenceof MAFLDandT2DM hasahigh prevalencerate and accelerates disease progression，imposingasignificant disease burdenonpatientsand posingamajorpublichealth challenge. MAFLDand T2DMmutuall influence eachother，sharing commonpathogenic mechanisms.Developing efectiveco-management strategiesforMAFLDandT2DMisacritical clinicalpriority.Thisreviewelaboratesonrecentadvances intheepidemiology， pathogenesis，screening，monitoring，andtreatmentof T2DMcombined with MAFLD.It highlights thattheco-existence of T2DMand MAFLD has become acommon clinical phenomenon with eachcondition exacerbating the development and progresionof theother.ScreeningforMAFLDshouldbeimplementedinT2DMpatients.Non-invasivediagnostictolssuchasthe Fibrosis4IndexandNAFLDFbrosis Scorecanbeusedforroutinescrening，though theiraccuracyrequiresfurtervalidation. Additionally，medicationslikesodium-glucosecotransporterinhbitorsandlucagon-likepeptide1receptoragonstshaveben showntoimproveoutcomes inpatientswithT2DMandMAFLD，efectivelypreventingcardiovascularevents.ThisreviewprovidesreferencefortheoptimizationofclinicaldiagnosisandtreatmentstrategyofT2DMcombinedwithMAFLDandtheformulationof clinical "glycohepatic co-management" strategy.

【Key words】Metabolic dysfunction-assciated fatty liver disease；Type2 diabetes melltus；Co-management of MAFLD and T2DM；Metabolic diseases；Chronic liver disease

代谢相关脂肪性肝病（MAFLD）又称为非酒精性脂肪性肝病（NAFLD），疾病谱涵盖单纯脂肪变性、代谢相关脂肪性肝炎（MASH）、肝纤维化、肝硬化和肝癌。（剩余17281字）