脂质代谢异常与抑郁症发展的关联及机制研究进展

【关键词】抑郁症；脂类代谢；机制； α- 突触核蛋白；多不饱和脂肪酸【中图分类号】R749.41R349.11【文献标识码】A DOI：10.12114/j.issn.1007-9572.2024.0233

【Abstract】Lipid metabolism isakeyphysiological process in the human body，anditsdisruption is closelyomected with thensetandevelopmentofepression.Nevertheless，asystematiccolltionofteseassiationsiscurrentlideate. Thisarticlecomprehensivelyexploredthechangesinlipidmetabolisminpatientswithdepresionandelaboratesondisordersin whichdisordersoflipidmetabolismwereco-morbidlyassociatedwithdepresion，suchasoverweight，obesityndmetabolic syndrome.Inaddition，thearticlesummarisedfiveintrinsic mechanisms bywhichabnormalities in lipid metabolism were asociated with the development of depression：overexpression of SNCA genes and abnormal accumulation of α -Syn，iron death，dysbiosisof gutmicrobiota，impairmentoftochondrialqualitycontrolsystems，andchroicstress.Finally，thisarticle suggestedfutureresearchdirectionsaimedatprovidinganewperspectiveandresearchbasisfortheearlydiagnosisandtreatment of depression.

【Key words】 Depression；Lipid metabolism；Mechanism；Alpha-synuclein；Polyunsaturated fatty acids

抑郁症是一种严重的心理健康障碍，特征包括情绪低落、兴趣缺失、睡眠障碍等，严重干扰个人的日常功能和生活质量，甚至可能导致自杀。（剩余21243字）