血必净联合亚胺培南与血液净化治疗脓毒症休克的疗效及安全性
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中图分类号 R631.2文献标识码A文章编号 2097-7964（2026）03-189-04
【Abstract】ObjectiveTo analyze theclinical eficacy and safetyof Xuebijing combined with imipenemand blood purification inthetreatmentofseptic shock patients.MethodsAtotal of90patients with septicshock admitted to the First People's Hospitalof Zigong City fromJanuary 2022to January 2025were selectedastheresearch objects.Based on the principleofbalancedandcomparable baselinedata such asgenderandage between groups，theyweredivided into the observation groupandthe control group by therandom number table method， with 45 cases in each group.The control group was treated with imipenemcombined with blood purification，while theobservation group Was treated with Xuebijing in additiontothecontrolgroup.Thelevelsofinflammatoryfactors[C-reactiveprotein（CRP）procalcitonin（PCT），interleukin6（IL-6）and tumor necrosis factor-α（TNF-α）]，severityacute physiologyandchronic health evaluation I（APACHE）and sequential organ failure asessment（SOFA）]sores beforeandaftertreatment，aswellas，intensivecareunit（ICU）stayand incidenceofcomplications betweentwo groups werecompared.ResultsBefore treatment，therewas no statisticallysignificant difference inthe levelsof various inflammatoryfactors （CPR，PCT，IL-6andTNF-α）betweenthetwo groupsofpatients （204号 （P>0.05） .After treatment，thelevelsofvarious inflammatory factors inboth groups decreased，butthose intheobservation group were lower than those in the control group，and the difference was statistically significant （P<0.05） .Before treatment， there was no statisticallysignificant diference in the APACHEIIand SOFA scores between the two groupsof patients （P>0.05） ： After treatment， theAPACHEIadSOFAscoresofboth groupsdecreased，butthoseoftheobservationgroup werelowerhan those of the control group，and the difference was statistically significant （P<0.05） .Thelengthof ICU stayin theobservation group was shorter than that in the control group，and the difference was statistically significant （P<0.05） .The incidence of complications in the observation group （4.44%） ）was lower than that in the control group （17.78%） ，and the difference was statisticallysignificant （P<0.05） .Conclusion The combination of Xuebijing and imipenem with blood purification therapy can efectivelyduceteifammatoryesposeofpatietsithsticsckalleviateteseverityoftecondiion，shortenCUstay.
【Key words】 Septic shock; Blood must be clean; Imipenem; Blood purification; Inflammatory factors; Safety
脓毒症休克是临床重症医学领域较为多发的急危重症类型，其病理本质是感染诱发机体产生过度炎症反应，进而引发微循环障碍，最终导致多器官功能衰竭的严重综合征，其病死率居高不下，对患者生命安全构成重大威胁，也给医疗系统带来沉重负担[。（剩余5796字）