基于中草药囊泡探析中药归经理论的科学内涵

关键词：中药归经；科学内涵；植物源性纳米囊泡；中草药囊泡；中草药中图分类号：R28文献标志码：A 文章编号：1003-9783（2026）03-0552-06doi： 10.19378/j.issn.1003-9783.2026.03.018

Elucidating the Scientific Connotation of TCMMeridian Tropism Theory Based on Chinese Herbal Vesicles

CAO Yingqi'，SHEN Jiawen¹，SHEN Wencong，WU Zhengting1，MEI Quanxi，LIN Xingdong²，LUO Yiwen²， SUN Li²，YE Jianglin²，YOU Qi'，XIA Yuanyuan1， ZHAO Qing1.2.34， ZHAO Kewei 2，3，4 （1. The Third School of Clinical Medicine，Guangzhou Universityof Chinese Medicine，Guangzhou Guangdong，China；2.The Third Affiliated Hospitalof Guangzhou UniversityofChinese Medicine，Guangzhou Guangdong，China；3.Guangdong Engineering Research Centerof Chinese Herbal Vesicles，Guangzhou Guangdong，China；4.Guangdong Pilot Platform for Chinese Herbal Vesicles，Guangzhou Guangdong，China）

Abstract：As one of the core concepts in traditional Chinese medicine（TCM），the theory of meridian tropism is crucialfor explainingthe mechanismsofTCMeficacy.However，itlacksaclearscientificexplanation.Chineseherbal medicine-derived extracelularvesicle-like particles （CHM-EVLP），asa prominent categoryof plant-derived nanovesicles，contain various active components（such asRNAs，proteins，and lipids）.They can not only synergisticallregulate multiple pathways toexertholistictherapeutic efects butalso enable targeteddelivery，naturally combiningthe functions of both“carrier”and“drug".Thisaligns highly withthecore connotationof "reaching the targetlocationandachieving the efect"inthe TCM meridian tropism theory.Therefore，CHM-EVLP hold promise for providing averifiable microscopic material basis for this theory.Thisarticle reviews the definition，composition， extraction and characterization methods，and core features of CHM-EVLP.It preliminarilyanalyzes the feasibilityof using the CHM-EVLP perspectiveto elucidate the material basis ofthe TCM meridian tropism theory from two aspects ：thetargeted propertyofCHM-EVLPmatching the directionalatributeof "meridian tropism"，andthemulti-component nature of CHM-EVLP matching the pharmacodynamic atribute of "meridian tropism".This provides theoretical support and a practical pathway for the modernization of TCM.

Keywords：TCM meridian tropism；scientific connotation；plant-derived nanovesicles；Chinese herbal medicinederived extracellular vesicle-likeparticles；Chinese herbal medicine

中药归经理论以“归”为药物作用归属、“经”为脏腑经络的导向，阐释了中药对机体特定部位的选择性作用，是中医辨证施治与组方配伍的核心理论，具有重要的现代研究价值。（剩余12725字）