基于调节季铵盐臂长策略的抗菌聚氨酯的制备

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中图分类号：TQ323.8 文献标志码：A

Preparation of Antibacterial Polyurethane Based on Strategy of Adjusting Arm Length of Quaternary Ammonium Salt

LYUXingshuang， SUN Yufang，LI Jingxuan，FU Xiaohui，LI Zhibo （Shandong Key Laboratory ofHigh Performance Polyolefin Materials and Recycling，College of Polymer Science and Engineering， Qingdao University of Science and Technology， Qingdao 266042， Shandong， China）

Abstract：Polyurethane（PU）is widelyused inthefieldofbiomedical implants duetoits tailorable mechanical properties， excellnt processbilityand goodbiocompatibilityHowever，planktonicbacteriaoftenadhere tothesurfacesofPUimplants， which maycause infectionsand threaten patient health.Therefore，the development of polyurethane materials with high antibacterial eficiencyhassignificantresearchvalue.Using bromomethylalkylacidastherawmaterial，threequaterary ammonium salt （QAS） chain extenders Bn （n=1，3，5 ） with different alkyl arm lengths were synthesized by introducing QAS groups and dihydroxyl structures，andregulating the alkylchain linkerlengths （1，3，5carbon atoms，respectively）between the bromine atoms and ester groups inbromomethylalkylacid.After the pre-polymerizationof polycaprolactone diol（PCL） with hexamethylenedisocyanate（HDI），aco-chains extensionreaction wascariedoutusing14-butanediol（BDO）andBnto prepare polyurethane （PU-Bn）with adjustable alkylarm lengths between the QAS cation center and the main chain.The influence ofthe QASarm length on the thermodynamic properties，antibacterial properties and hemolytic properties of the materialwassystematicallystudied.Theresultsshow thatallU-Bnmaterialsexhibitgood thermal stabilityexcellnt mechanical propertiesand a low hemolysis rate.The antibacterial experiment revealsthat theQASarm length hasa significant impactontheantibacterialperformance.Polyurethane withashorterarmlengthdemonstrates beterantibacterial ability，and the antibacterial effect follows the order： PU ⋅B1>PU-B3>PU-B5

Key words： polyurethane; antibacterial; quaternary ammonium salt; structure; property

聚氨酯（PU）通常是由异氰酸酯与多元醇/多元胺和扩链剂聚合而成[1-4]，因具有良好的力学性能、优异的加工性能和生物相容性，被广泛用于软骨支架[5.6]、膝关节半月板支架[7，8]、导尿管[，0]和血管移植物[，2] 等生物医疗器械领域。（剩余15221字）