基于“脾主运化”探讨针灸治疗慢性疲劳综合征的“肠道菌群-线粒体”轴调控机制

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关键词：针灸治疗；脾主运化；慢性疲劳综合征；肠道菌群；线粒体能量代谢；调控机制中图分类号：R246.9 文献标志码：A 文章编号：1007-3213（2026）02-0433-06DOI：10.13359/j. cnki. gzxbtcm.2026. 02.022

Exploring the Regulatory Mechanism of the “Gut Microbiota-Mitochondria" Axis in Acupuncture Treatment for Chronic Fatigue Syndrome Based on the Theory of“Spleen Governing Transportation and Transformation"

WANG Zhonghao'，LIU Ting²，LIAO Muxi³，4

（1.GuangzhouUniversityofChineseMedicine，Guangzhou5106Guangdong，China；2.Cliford Hospital，Guangzhou511496 Guangdong，China；3.ShenzhenNanshanDistrictChineseMedicineHospital，NanshanHospitaloftheFirstAfiliatedHospitalof Guangzhou UniversityofChinese Medicine，Shenzhen518O52Guangdong，China；4.TheFirstAfiliated HospitalofGuangzhou University of Chinese Medicine，Guangzhou 51O405 Guangdong， China）

Abstract：Chronic fatigue syndrome（CFS） is a complex disease characterized by persistent fatigue as the core symptom.The traditional Chinese medicine theory of“Spleen Governing Transportation and Transformation” providesaunique perspective for its treatment.This study establishes a theoretical model of“Spleen Governing Transportation and Transformation-Microbiota Homeostasis-Mitochondrial Energy Metabolism”，proposing that acupuncture improves CFS through regulation of the“gut microbiota-mitochondria” axis，and analyzes the advantages and efcacy diffrences of acupuncture treatment. Results demonstrate that acupuncturecan restore gut microbiota homeostasis，inhibit mitochondrial oxidativestress，and enhance mitochondrial ATPsynthesis capacity，providing a new theoretical basis for acupuncture treatment of CFS.

Keywords：acupuncture treatment；spleen governing transportation and transformation；chronic fatigue syndrome（CFS）；gut microbiota；mitochondrial energy metabolism；regulatory mechanism

慢性疲劳综合征（chronic fatigue syndrome，CFS）是以不明原因引起的反复或持续发作 ⩾6 个月的慢性疲劳为典型表现，或伴随低热、神经肌肉疼痛、睡眠障碍及认知功能异常等多系统紊乱的临床综合征。（剩余9843字）