SWI/SNF相关蛋白A4缺失型肺癌临床及病理学特征分析

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Analysisclinical and pathological features SMARCA4-deficient lungcancerLiang Haihong，Yin Quanle， HanShusen，Yan Qingna.

【Abstract】ObjectiveTo investigate the clinical and pathological characteristics SMARCA4-deficient lung cancer.MethodsEighty-five cases with SMARCA4-deficient lung cancer were examined using the immunohistochemical EnVision two-step method，and the expression BRG1 protein in different pathological tisue types was compared.ResultsOf the 85 cases with SMARCA4-deficientlung cancer，73 were male patients，with67 having a long-termsmoking history.Thepatients'agesranged from4O to77 years，witha median age 64years.The histopathological clasificationswere as follows：poorlydiferentiated/undiferentited carcinoma （44%） ，adenocarcinoma （31%） ），mixed carcinoma （16%） ，high-grade neuroendocrine carcinoma（ 6% ），and squamous cell carcinoma（ 4% ）.Immunohistochemical findings demonstrated that 80% （68/85） patients had a complete loss BRG1 protein，while the remaining patientsshowed weak or partial expression BRG1.ALK testing was negative in all45 patients who underwent the assy.ConclusionSMARCA4-deficient lung cancer hasalow incidence，high invasivenesandpoor prognosis，and encompasses arange histopathological types.Its diagnosis should be based on clinicopathological characteristicsand immunohistochemical examination.This type lung cancer is insensitive to radiotherapy and chemotherapy.

【Key Words】 Lung neoplasms；Pathology，molecular;SMARCA4 deficiency

世界卫生组织（WHO）在2021年胸部肿瘤分类系统中，在其他上皮性肿瘤框架内新增一类SWI/SNF相关蛋白A4（SMARCA4）缺陷型未分化肿瘤，诊断需依赖于形态学，免疫组织化学和分子生物学。（剩余9132字）