姜黄素抗抑郁作用机制的研究进展

·综述·

打开文本图片集

中图分类号R285；R965 文献标志码A 文章编号1001-0408（2025）09-1147-06

DOI 10.6039/j.issn.1001-0408.2025.09.22

ABSTRACTCurcumin is anatural yellwpigment，anatural phenolic antioxidant extractedfromtherhizomesof Curcuma longa andCurcumaeRhizomaofthegingerfamily，withanti-inflammatory，anti-tumorandantioxidant properties.Inrcentyears，ithas beenfoundthatcurcuminalsohasgoodantidepressantproperties，nditisconsideredasafeandefectiveantidepressntpotential drug.Themechanismofcurcumin'santidepressanteficacymainlyincludesregulatingneurotransmiters，modulatingthe hypothalamic-pitaryadrealaxis，egulatingbaidriedeurotropicctoribiinguroflammationibiigidatie stress，andregulatinggutmicrobiota，etc.andthereisanoverlappngandsynergistictherapeuticefectoftheabove mehanisms. Atpresent，theantidepressantmechanismofcurcuminisstillnotfullyunderstod，andwillbecombinedwithmulti-omics technology，new formulation technology，and clinical trials to obtain further breakthroughs in the future.

KEYWORDS curcumin；depression；neurotransmitter；inflammatory response；oxidative stress；mechanism

抑郁症是一种临床常见的慢性、复发性精神疾病，严重影响患者的生活质量，甚至增加了死亡风险。（剩余14139字）