替尔泊肽用于2型糖尿病和长期体重管理的快速卫生技术评估

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中图分类号 R977.1+5；R587 文献标志码A 文章编号 1001-0408（2025）09-1141-06

DOI 10.6039/j.issn.1001-0408.2025.09.21

ABSTRACTOBJECTIVEToevaluatetheefficacy，safetyandcost-efectivenessof tirzepatidefordiabetes mellitus type （T2DM）andlong-term weight management，and provideevidence-basedbasisforclinicaldrug treatmentand health insurance policy formulation.METHODS Computer searches wereconducted in Embase，PubMed，the Cochrane Library，CNKIand health technologyassssment（HTA）oicialwebsitefromtheirinceptiontoOctober1st224tocollctHTAreport，systematicreview/ meta-analysisandpharmacoeconomicstudyontirzepatideforthetreatmentof T2DMorforweightmanagement.Afterdata extractionandqualityevaluation，descriptiveanalysis was performedontheresearch results.RESULTSTotally18 papers were included，including14systematicreviews/meta-analysesand4 pharmacoeconomics studies，andnoHTAreport wasretrieved.In termsof efficacy，most results showed that the tirzepatide 1 0 m g and were significantly better than other glucagon-like peptide-1（GLP-1） receptor agonists in reducing glycosylated hemoglobin，body weight，and waist circumference（ .In termsof safety，comparedwithoterG-1receptoragonists，tizepatidedidnotincreasetheincidenceofgastrointestialrelated adverse events（AE），the incidence of AE of grade ⩾ 3 ，or the incidence of severe hypoglycemia（ P>0 . 0 5 ）.However，tirzepatide 1 5 m g maysignificantly increased the incidence of hypoglycemia and therateof discontinuation due toadverse reactions（ P < 0.05）.Intermsofcost-effectiveness，basedonthebackgroundofforeignpharmacoeconomicstudies，tirzepatidewasmorecostefectivecomparedtosemaglutideandliraglutideinthetreatmentofT2DMorforweight management.CONCLUSIONS Tirzepatide at dosesof and hasgood efficacy and safety for the treatment of T2DM and for long-term weight management. However，when using the 1 5 m g dose of tirzepatide，close monitoring is required due to the risk of hypoglycemia and discontinuationduetoadversereactions itmaypose.Basedonpharmacoeconomic studiesconductedabroadresults，tirzepatide exhibits economic advantages.

KEYWORDStirzepatide；diabetesmellitus type2；obesity；rapid health technology assessment

世界肥胖联盟2024年的研究数据显示：2020年全球约有8.1亿成年人患有肥胖症，预计到2030年患肥胖症的人数将达到12.5亿[]。（剩余15713字）