HA-RGD对细胞活性因子修复功效影响的研究

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【摘要】目的 通过多种检测方法分析HA-RGD对细胞活性因子修复功效的影响。方法 利用一定的比例构建HA-RGD、细胞活性因子组合物1和组合物2，在细胞水平和人体水平分别评估其对皮肤的修复效果。结果 组合物1和组合物2中受试者人体安全斑贴试验结果均为阴性，未出现不良反应，安全性良好；基于细胞迁移实验，组合物1和组合物2与空白对照相比，相对迁移平均值显著升高（P

【关键词】多氨基酸多糖缩合物；细胞活性因子；皮肤修复

中图分类号：R392 文献标识码：A 文章编号：1004-4949（2023）18-0070-04

Study on the Effect of HA-RGD on the Repair Efficacy of Cell Active Factor

ZHANG Nan， ZHANG Ting-ting

（Xi’an Bohong Biotechnology Co. Ltd.， Xi’an 710032， Shaanxi， China）

【Abstract】Objective To analyze the effect of HA-RGD on the repair effect of cell active factors by various detection methods. Methods HA-RGD， cell active factor composition 1 and composition 2 were constructed in a certain proportion， and their repair effects on skin were evaluated at the cellular level and human level， respectively. Results Human safety patch test of subjects in combination 1 and combination 2 were negative， no adverse reactions occurred， and the safety was good. Based on the cell migration experiment， the average relative migration of composition 1 and composition 2 was significantly higher than that of blank control （P

【Key words】Polyamino sugar condesate； Cell active factors； Skin repair

间充质干细胞（mesenchymal stem cells，MSCs）作为一种能够自我更新且具有多向分化潜能的成体干细胞[1，2]，其在培养过程中会分泌大量的细胞因子，是除外泌体外另一具有广泛生物学活性的小分子蛋白质，富含细胞活性关键的信息传递物质，这种传递物质被称为细胞活性因子[3]。（剩余6071字）