ICU病人肠内营养不耐受危险因素的Meta分析

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Abstract  Objective：To investigate the risk factors of enteral nutritional intolerance in intensive care unit（ICU） patients through Meta-analysis.Methods：Literature on enteral nutritional intolerance in ICU patients was reviewed from WanFang Database，CNKI，VIP and CBM.The relevant data were extracted and analyzed with RevMan 5.3 software.Results：A total of 20 articles were included.The results of Meta-analysis showed that intra-abdominal pressure（OR＝3.53，95％CI 2.42-5.16，P＜0.000 01），APACHE Ⅱ score（OR＝2.17，95％CI 1.26-3.74，P=0.005），application of acid-suppressive drugs（OR＝3.56，95％CI 1.32-9.58，P=0.01），fasting time>72 h（OR＝2.06，95％CI 1.47-2.88，P＜0.000 1），implementation days of enteral nutrition（OR＝4.00，95％CI 3.55-4.45，P＜0.000 01），age（OR＝2.05，95％CI 1.51-2.79，P＜0.000 1）and application of antibiotics（OR＝5.89，95％CI 1.88-18.41，P=0.002） were risk factors for enteral nutrition intolerance.Conclusion：The available evidence shows that intra-abdominal pressure，APACHE Ⅱ score，application of acid-suppressive drugs，fasting time>72 h，implementation days of enteral nutrition，age，application of antibiotics are risk factors for enteral nutritional intolerance.Preventive nursing of enteral nutritional intolerance should be strengthened in combination with risk factors to reduce the incidence of nutritional intolerance.

Keywords  enteral nutrition intolerance;intensive care unit;risk factors;Meta-analysis;evidence-based nursing

摘要  目的：通过Meta分析探讨重症监护室（ICU）病人肠内营养不耐受的危险因素。（剩余9570字）