11种非药物干预方法对乳腺癌病人癌因性疲乏影响的网状Meta分析

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Effect of 11 non-drug intervention methods on cancer-related fatigue in breast cancer patients：a network Meta-analysis

FU Jingjing，LIAO Xilin，LYU Kaiyue，WU Jiahui，LI Yuhang，WANG JintaoSchool of Nursing，Guangxi University of Chinese Medicine，Guangxi 530001 ChinaCorresponding Author LIAO Xilin，E-mail：2535369326@qq.com

Abstract Objective：To evaluate the intervention effect of 11 non-drug intervention methods on cancer-related fatigue in breast cancer patients based on network Meta-analysis.Methods：Relevant literature was retrieved from databases such as CNKI，WanFang Database，CBM，VIP，PubMed，Web of Science，MedLine，and the Cochrane Library，from the establishment of the database to February 23，2023. Literature was screened according to the inclusion and exclusion criteria，data was extracted，quality was evaluated，and Stata 16.0 software was used for data analysis.Results：A total of 26 studies were included，involving 2 333 patients and 11 non-drug intervention methods. The results of the network Meta-analysis showed that compared with routine care，cognitive behavioral therapy，massage therapy，and aerobic exercise can all alleviate cancer-related fatigue in breast cancer patients （P<0.05）. Among the 11 non-drug intervention methods included，there were statistical differences between cognitive behavioral therapy and aerobic exercise，narrative care，music therapy，mindfulness-based stress reduction therapy，Yoga，group therapy，dance therapy，resistance training，and Pilates. There was a statistical difference between massage therapy and music therapy，mindfulness-based stress reduction therapy，Yoga，group therapy，dance therapy，resistance training，and Pilates （P<0.05）. The cumulative ranking probability map showed that the best intervention method for cancer-related fatigue in breast cancer patients was cognitive behavioral therapy. The surface under the cumulative ranking area （SUCRA） was 95.3%，followed by massage therapy （SUCRA 94.3%） and aerobic exercise （SUCRA 66.4%）.Conclusions：Existing evidence shows that a variety of non-drug intervention methods could alleviate cancer-related fatigue in breast cancer patients，among which cognitive behavioral therapy has the best effect.

Keywords non-drug intervention;breast cancer;cancer-related fatigue;network Meta-analysis;cognitive behavioral therapy;massage therapy;aerobic exercise;evidence-based nursing

摘要 目的：通过网状Meta分析评价11种非药物干预对乳腺癌病人癌因性疲乏的干预效果。（剩余13138字）