肾移植术后患者创伤后应激症状与脑灰质体积减小的相关性研究：基于体素形态学测量方法

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中图分类号：R749.2 文献标志码：A DOI：10.7652/jdyxb202505020

Correlation between post-transplant post-traumatic stress symptoms and gray matter volume reduction after kidney transplantation： a voxel-based morphometry study

WANG Xinyi1，ZHU Xinyi1，MU Junya1，OUYANG Yuanshuo²，WANG Yuchen1， GUAN Chuxin1，MA Shaohui1，ZHANG Ming1

（1. Department of Medical Imaging，The First Afiliated Hospital of Xi'an Jiaotong University，

Xi'an 710o61; 2. Department of Human Anatomy and Histology & Embryology， School of Basic Medical Sciences，Xi'an Jiaotong University Health Science Center，Xi'an 71oo61，China）

ABSTRACT： ObjectiveTo investigate alteration in brain gray mater volume in kidney transplant recipients （KTRs）and itscorelation with post-traumatic stress symptoms （PTsS）in KTRs soas to provide neuro-imaging evidence for early detection and intervention of PTSSin KTRs. MethodsForty-six KTRs and 46 age-，sex-，and education-matched heath control（HCs）underwent brain MRI scanning with 3D T1-weighted structural images. Voxel-based morphometry（VBM） was applied to compare the gray mater volume between the two groups.For regions with significant differences in gray matter volume between KTRs and HCs，we analyzed the correlations with the Impact of Event Scale-Revised （IES-R） scores，which assssthe severity of PTSs.ResultsCompared to HCs，KTRs showed significant reductions in gray matter volume in the bilateral precentral gyrus，middle frontal gyrus，supplementary motor area，medial paracingulate gyrus，and bilateral middle temporal gyrus（all P<0.05 ， TFCE-FWE correction）.The gray mater volume of the left middle frontal gyrus in KTRs was negatively correlated with their IES-R scores （ r=-0.235 ， P=0.022 ）.ConclusionKTRs exhibit abnormal gray matter volume，and the gray matter volume of the left middle frontal gyrus is correlated with the severity of PTSs.

KEY WORDS： kidney transplantation; post-traumatic stress symptom;gray mater volume; Impact of Event Scale （IES）；magnetic resonance imaging

肾移植是目前全球治疗终末期肾病的最佳疗法[1]，显著降低患者的死亡率并改善生活质量[2]。（剩余9003字）