吸烟与认知功能下降的关系：西安农村人群4年前瞻性队列研究

打开文本图片集

中图分类号：R741 文献标志码：ADOI：10.7652/jdyxb202505008

Relationship between smoking and cognitive decline： a 4-year cohort prospective study on rural population in Xi'an

LIU Jie1，WANG Zihan¹，GUO Xiaojuan1，SHANG Suhang1 ， CHEN Chen1，WANG Jingyi²，QUQiumin1，WANG Jin1 （1.Department of Neurology，The First Affiliated Hospital of Xi'an Jiaotong University， Xi'an 7loo6l；2.Department of Encephalopathy，Huyi Hospital of Traditional Chinese Medicine，Xi'an 71o3oO，China）

ABSTRACT： Objective This study examined the assciation between smoking and cognitive decline through a cohort n rural population in Xi'an.MethodsData were collcted from the cognitive impairment cohortof midleaged and elderly people inruralareas of Xi'an.Thecohort selected the populationaged 4O years and above in rural Xi'an.The baseline surveywas completed between October 2O14 and March 2015，and two folow-up visits were conducted in 2Ol6and 2O18.This studytook thebaseline cognitively normalpopulationof this cohort asthe research subjects.According to the survey results in 2O18，the population was divided into three groups according to smoking status：smoking，quiting and non-smoking. Cognitive function was asessed byMini-Mental State Examination （MMSE）.△MMSE（2014 rating-2018 rating） ⩾2 was defined as cognitive decline，and △MMSE <2 was defined as cognitive stability.Binary Logistic regresion model and stratified analysis were used to analyze the relationship between smoking and cognitive decline and the influence of age on the relationship.Results A total of1 289 subjects were included in this study.According to smoking status in 2Ol8，they were divided into non-smokers （910， 70.6% ， smokers（335， 26.0% ），and ex-smokers（44， 3.4% . In the total population，there was no significant difference in the incidence of cognitive decline among non-smokers，smokers and ex-smokers （17.3% vs. 16.1% vs. 15.9% ， P= 0.80）.When stratified by age，there was no significant diference in the incidence of cognitive decline among the three groups in the subgroup of age <65 years ， P=0.365. . In the subgroup of age ⩾ 65 years，no significant difference was found in the incidence of cognitive decline among non-smokers，smokers and ex-smokers （20.8% vs. 30.9% Vs. 27.3% ， P=0.306） .After adjusting for confounding factors，smokers had a significantly higher risk of cognitive decline than non-smokers（ OR=14.139 . 95% CI：1.541—129.705; P=0.019; 。（剩余8558字）