艾地苯醌治疗缺血性脑卒中后抑郁的临床研究

打开文本图片集

摘 要 目的：探讨艾地苯醌治疗缺血性脑卒中后抑郁的临床效果。方法：选取60例缺血性脑卒中后抑郁患者，依据治疗方式将其分为对照组（29例）和观察组（31例）。在常规治疗基础上，对照组给予安慰剂治疗，观察组给予艾地苯醌治疗，治疗2个月后，比较两组炎性指标及5-HT、5-HIAA水平。结果：两组治疗后IL-6、IL-23、TNF-α水平低于治疗前，且观察组水平更低；5-HT水平升高，5-HIAA水平降低，且观察组改善显著（P

关键词 缺血性脑卒中后抑郁 艾地苯醌 炎性指标

中图分类号：R979.9； R747.9 文献标志码：B 文章编号：1006-1533（2021）17-0030-02

Clinical study on idebenone in the treatment of depression after ischemic stroke

SONG Yuanqing

（Department of Neurology， the First People’s Hospital of Jiujiang City， Jiujiang 332000， China）

ABSTRACT Objective： To investigate the clinical effect of idebenone in the treatment of depression after ischemic stroke. Methods： Sixty patients with post-stroke depression were selected and divided into a control group （29 cases） and an observation group （31 cases） based on their treatment methods. On the basis of conventional treatment， the observation group was treated with idebenone while the control group only with placebo. The inflammatory indexes， 5-HT and 5-HIAA levels were compared between the two groups 2 months after treatment. Results： The levels of IL-6， IL-23， TNF-a and 5-HIAA were significantly lower while the 5-HIAA levels were higher after treatment than before， and furthermore they were more significant in the observation group （P

KEy WORDS depression after ischemic stroke； idebenone； inflammatory index

缺血性脑卒中后抑郁是脑血管疾病中常见的并发症之一，常表现为抑郁、焦虑、失眠等精神系统障碍，对脑血管疾病患者预后转归存在极大威胁[1]。（剩余3728字）