铁死亡在乳腺癌治疗中的研究进展

［摘要］ 铁死亡是一种不同于凋亡、坏死的细胞程序性死亡，与许多生物过程有关。一些研究发现，铁死亡能协同化疗、放疗、免疫治疗等，增强对乳腺癌的疗效，诱导铁死亡可能成为肿瘤治疗的新靶点。本文对铁死亡的发生途径及其在乳腺癌治疗中的研究进行了综述。

［关键词］ 铁死亡；乳腺肿瘤；脂质过氧化作用；综述

［中图分类号］ R737.9

［文献标志码］ A

［文章编号］ 2096-5532（2024）06-0937-04

doi：10.11712/jms.2096-5532.2024.60.204

［开放科学（资源服务）标识码（OSID）］

［网络出版］ https：//link.cnki.net/urlid/37.1517.R.20250113.1932.002;2025-01-14 12：03：25

Research advances in ferroptosis in the treatment of breast cancer

LIU Zeyu， LIU Jiannan， SUN Ping

（Department of Oncology， The Affiliated Yantai Yuhuangding Hospital of Qingdao University， Yantai 264000， China）

［Abstract］ Ferroptosis is a type of programmed cell death different from apoptosis and necrosis and is associated with many biological processes. Several studies have shownthat ferroptosis can synergize with chemotherapy， radiotherapy， and immunotherapy to enhance the efficacy of treatment for breast cancer， and induction of ferroptosis may become a new target in tumor therapy. This article reviewsthe pathways of ferroptosis and related studies in the treatment of breast cancer.

［Key words］ ferroptosis; breast neoplasms; lipid peroxidation; review

铁参与细胞生长和增殖的许多过程，铁死亡是一种以铁依赖性的脂质过氧化为主要特征的细胞程序性死亡。（剩余13018字）