宫颈电切术联合重组人干扰素α2b对宫颈上皮内瘤样病变伴高危型HPV感染的疗效

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【摘要】目的：分析宫颈电切术联合重组人干扰素α2b对宫颈上皮内瘤样病变伴高危型HPV（HR-HPV）感染的疗效。方法：选取我院2020年4月—2022年4月的80例宫颈上皮内瘤变伴HR-HPV感染患者，随机将其分成为两组。对照组采取宫颈电切术，观察组联用重组人干扰素α2b。结果：观察组的宫颈管息肉样增生发生率、宫颈上皮内瘤变复发率和宫颈管狭窄发生率更低（P0.05），治疗后，两组的血清IgG、TNF-α、IgM、IL-6和IgA水平均明显改善（P

【关键词】宫颈电切术；重组人干扰素α2b；高危型HPV；宫颈上皮内瘤样病变

Efficacy of cervical resection combined with recombinant human interferon α2b on cervical intraepithelial neoplasia with high-risk HPV infection

LIU Wenmin， LIU Xia， DU Xiaohong

Hospital of Traditional Chinese Medicine， Wudu District， Longnan， Gansu 741000， China

【Abstract】Objective： To analyze the curative effect of cervical resection combined with recombinant human interferon α2b on cervical intraepithelial neoplasia with high-risk HPV （HR-HPV） infection. Methods： A total of 80 patients with cervical intraepithelial neoplasia with HR-HPV infection in our hospital from April 2020 to April 2022 were selected and randomly divided into two groups. The control group received cervical resection， and the observation group received recombinant human interferon α2b. Results： The incidence of cervical polypoid hyperplasia， cervical intraepithelial neoplasia recurrence and cervical stenosis were lower in the observation group （P0.05）. After treatment， the levels of serum IgG， TNF-α， IgM， IL-6 and IgA in the two groups were significantly improved （P

【Key Words】Cervical resection； Recombinant human interferon α2b； High-risk HPV； Cervical intraepithelial neoplasia

宮颈上皮内瘤变作为宫颈浸润癌的癌前病变，可以有效反映宫颈癌的发生和发展过程，如果患者没有及时进行有效的干预治疗，会进一步发展成宫颈癌，对其生活质量和身体健康造成严重的不良影响，甚至会威胁其生命安全[1]。（剩余4133字）