中医药调控代谢重编程干预肝细胞癌的研究进展

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中图分类号：R735.7文献标志码：A 文章编号：1003-9783（2025）03-0469-10

doi：10.19378/j.issn.1003-9783.2025.03.017

Research Progress of Traditional Chinese Medicine Regulating Metabolic Reprogramming in Hepatocellular Carcinoma

CHEN Xinqiu’，ZHAO Xilin²，ZHU Xiaoyu1，HUANG Hanlin'，LIU Shuwei1，YAO Ruiwei’， ZHONG Chong 1，2，3 （1.The First Clinical Medical School，Guangzhou Universityof Chinese Medicine，Guangzhou 510405 Guangdong， China；2.State Key Laboratoryof Traditional Chinese Medicine Syndrome/The FirstAfiliated Hospital of Guangzhou University of Chinese Medicine，Guangzhou 510405 Guangdong，China；3.Department of Hepatobiliary and Pancreatic Surgery，The First Afiliated Hospital of Guangzhou University of Chinese Medicine，Guangzhou 510405 Guangdong，China）

Abstract：Metabolic reprogramming isconsidered to beoneof the hallmark features ofcancerand plays an important role in the process of hepatocellular carcinoma （HCC）development. HCC celsadapt to the changes in the tumour microenvironment and energy demand by reprogramming the metabolic pathways of sugars，lipids，amino acids，and othersubstances，therebyenhancing the proliferation，survival and invasion of tumourcelsandaccelerating tumour growth，metastasis，and drug resistance.In recent years，a large number of studies have found that Chinese herbal compounds and active ingredients can exert anticancer efects by interfering with HCC metabolic reprogramming，and positive progress has been achieved.This article systematically summarizes the research progressof Chinese herbal compoundand its activeingredients inexerting antitumour efects throug targeted metabolicreprogramming，witha view to providing theoretical basis for Chinese medicine to interfere in HCC through regulating metabolic reprogramming.

Keywords：hepatocellular carcinoma；metabolic reprogramming；traditional Chinese medicine；mechanism

肝细胞癌（HCC）是常见的消化道恶性肿瘤之一，占原发性肝癌的 80% 以上，同时也是造成癌症死亡的第三原因。（剩余25335字）