两样本孟德尔随机化分析4种常量营养素相对摄入量与肾结石的因果关系

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Two sample Mendelian randomization analysis of the causal relationship between relative intake of four constant nutrients and kidney stones

WANG Cong1，2，XI Yujia1，2，WANG Zhenxing2，JIA Yijun1，2，HAO Chuan2

（1.The Second Clinical Medical College，2.Department of Urology，The Second Hospital，Shanxi Medical University，Taiyuan 030001，China）

ABSTRACT：Objective To investigate the causal relationship between the relative intake of dietary components （including carbohydrate，added sugar，protein，and fat） and kidney stones using two sample Mendelian randomization （MR）.Methods The genetic instrumental variables （IVs） from genome-wide association study （GWAS） statistics，exposure-related summary data from the SSGAC genome study，and kidney stone data from the Finn Gen Consortium were collected，which were then analyzed with inverse variance weighting （IVW）.The MR results and sensitivity were assessed with MR-Egger，weighted median，MR-PRESSO test，Cochran’s Q test，leave-one analysis，and Steiger filter.Results IVW results showed that the relative intake of carbohydrate （OR=2.01，95%CI：1.02-3.96，P=0.042） and added sugar （OR=2.07，95%CI：1.00-4.29，P=0.049） had a causal relationship and were risk factors for the development of kidney stones.Relative intake of protein （OR=0.70，95%CI：0.38-1.29，P=0.249） and fat （OR=0.79，95%CI：0.27-2.35，P=0.671） were not associated with kidney stones.Sensitivity analysis showed no heterogeneity or pleiotropy （P>0.05）.Conclusion Relative intake of carbohydrate and added sugar are risk factors for kidney stones，suggesting that limiting carbohydrate and added sugar intake may prevent the development of kidney stones.

KEY WORDS：Mendelian randomization; kidney stones; diet; carbohydrate; added sugar

摘要：目的 通过两样本孟德尔随机化（MR）探讨饮食成分相对摄入量（即碳水化合物、添加糖、蛋白质和脂肪）与肾结石（KSD）之间的因果关系，为KSD的预防提供参考。（剩余14012字）