前列腺导管腺癌合并黏液腺癌1例报告及文献复习

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Prostate ductal adenocarcinoma with prostate mucinous adenocarcinoma： a case report and literature review

NIHATI Rexiati1，CAO Hong2，HAN Weizhe1，CHEN Zhizhuang1，SHI Jiageng1，WU Zhuang3，LYU Yuan4，JIANG Chunyong5，LIU Tao1，WANG Yongzhi1，WANG Xinghuan1，YANG Zhonghua1

（1.Department of Urology; 2.Department of Pathology，Zhongnan Hospital of Wuhan University，Wuhan 430072; 3.Department of Urology，China Resources WISCO General Hospital，Wuhan University of Science and Technology，Wuhan 430072; 4.Department of Urology，Huangmei County People’s Hospital，Huanggang 435500; 5.Department of Urology，Danjiangkou First Hospital，Danjiangkou 442700，China）

ABSTRACT：Objective To summarize the clinical manifestations，pathological characteristics，treatment options and prognosis of the world’s first case of prostate ductal adenocarcinoma （PDA） complicated with prostate mucinous adenocarcinoma （PMA）.Methods The clinical and follow-up data of a patient with PDA and PMA treated in Zhongnan Hospital of Wuhan University were retrospectively analyzed，and relevant literature in PubMed and CNKI databases was retrieved.Results The patient sought medical attention due to dysuria，frequent urination，urinary urgency and urinary pain for more than half a year，and was admitted to hospital 3 times in total.The initial diagnosis upon the first admission was benign prostatic hyperplasia complicated with prostatic abscess.After 2 months，the patient was readmitted due to worsening symptoms，received transurethral bladder neck incision+cystoscopy+transurethral plasma resection of the prostate，and postoperative diagnosis confirmed PDA with local PMA.Three months after surgery，the patient had bleeding.After auxiliary examinations revealed extensive metastasis，he received hormonal therapy.After 9 months，the patient died due to multiple lung metastases.Conclusion Early diagnosis has a significant impact on the treatment and prognosis，but there have been no previous reports of PDA combined with PMA，so the lack of specific biomarkers in the early stage has led to missed diagnosis or misdiagnoses.There is no specific treatment for PDA with PMA. Radical prostatectomy was not satisfactory in the treatment of this case.

KEY WORDS：prostate cancer; prostate ductal adenocarcinoma; prostate mucinous adenocarcinoma; prostate special antigen

摘要：目的 总结1例可能系世界首例报告的前列腺导管腺癌（PDA）合并前列腺黏液腺癌（PMA）患者的临床表现、病理学特征、治疗及预后情况（查新范围：英文、中文文献）。（剩余8082字）