免疫治疗在前列腺癌中应用的现状及展望

Immunotherapy for prostate cancer：current status and future perspectives

FANG Bangwei，ZHU Yao

（Department of Urology，Fudan University Shanghai Cancer Center，Department of Oncology，Shanghai Medical College，Fudan University，Shanghai 200032，China）

ABSTRACT：As an emerging cancer treatment modality，immunotherapy has shown promising efficacy in a variety of solid tumors，but it has failed to achieve a breakthrough in the treatment of prostate cancer.This review aims to provide an overview of the current applications of immunotherapy for prostate cancer，including immune，checkpoint inhibitors， cancer

vaccines and chimeric antigen receptor T，cell （CAR，T），briefly describe the mechanisms of various immunotherapy modalities，summarize the results of clinical trials，and discuss the challenges and prospects.

KEY WORDS：prostate cancer；immunotherapy；tumor immune microenvironment;immune，checkpoint inhibitors;cancer vaccines；CAR，T

摘要：免疫治疗作为一种新兴的癌症治疗方式，目前已经在多种实体肿瘤的治疗中表现出了良好的疗效，但在前列腺癌中该治疗方式未得到突破。（剩余18977字）