酒精、咖啡、绿茶和乳制品的摄入量与前列腺癌的关联：两样本孟德尔随机化研究
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Associations of alcohol，coffee，green tea and dairy products with prostate cancer：a two，sample Mendelian randomization study
CHAI Hongqiang，SHAO Jinkai，WU Ming，ZHAO Kejie，PANG Lei
（Department of Urology，The Fifth Clinical Medical College of Shanxi Medical University，Shanxi Provincial Peoples Hospital，Taiyuan 030012，China）
ABSTRACT：ObjectiveA two，sample Mendelian randomization method was used to explore whether there is a causal relationship between the intake of alcohol，coffee，green tea and dairy products and the incidence of prostate cancer （PCa），in order to clarify the risk factors for the incidence of PCa and find a prevention pathway for PCa.MethodsData of alcohol，coffee，green tea，dairy products and prostate cancer were collected with genome，wide association study （GWAS）.The causal relationship between their intake and the risk of PCa was analyzed with two，sample Mendelian randomization （2SMR）.MR analysis was conducted with inverse，variance weighting （IVW）.Sensitivity analysis was performed with weighted median，MR，Egger regression，Mendelian randomization
pleiotropy residual sum and outlier （MR，PRESSO） tests.Results Coffee intake （OR：0.994，95%CI：0.990-0.999，P=0.014） and green tea intake （OR：0.999，95%CI：0.998-0.999， P=0036） were negatively correlated with the risk of PCa.Alcohol intake （OR：0.997，95%CI：0.990-1.004，P=0.392） and dairy intake （OR：1.025，95%CI：0.983-1.069，P=0.256） were not associated with the risk of PCa.In weighted median，MR，Egger regression，and retention one method analyses，the results were robust without heterogeneity or pleiotropy.
Conclusion There was a causal association between coffee intake and green tea intake and the onset of PCa，but no causal association between alcohol intake and dairy intake and PCa onset.
KEY WORDS：Mendelian randomization；prostate cancer；causal inference；genome，wide association study；alcohol；coffee；green tea；dairy products
摘要：目的采用两样本孟德尔随机化方法探究酒精、咖啡、绿茶和乳制品的摄入量与前列腺癌（PCa）发病之间是否存在因果关系，以期帮助明确PCa的发病风险因素，从而帮助寻求PCa的预防途径。（剩余11463字）