外泌体在前列腺癌发生发展中的作用及在诊断方面的应用前景

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Mechanism of exosome in the pathogenesis of prostate cancer and its potential diagnostic application

XUE Jingdong，WU Denglong

ABSTRACT：Prostate cancer （PCa） is one of the most common tumors in men.In recent years，various researches on this disease and clinical applications have benefited patients.Exosome is a subclass of extracellular vesicles （EVs）.Many studies have explored the mechanisms of exosome in mediating epithelial mesenchymal transformation，angiogenesis，tumor microenvironment establishment，immune escape and drug resistance acquisition in PCa，which provides a new perspective for finding new diagnostic markers.This article reviews the role of exosome in the pathogenesis of PCa and its diagnostic application.

KEY WORDS：exosome；prostate cancer；tumor markers；tumor drug resistance；tumor microenvironment；cell to cell commu-nication；epithelial mesenchymal transformation

摘要：前列腺癌（PCa）是男性最常见的肿瘤之一，近年来随着对其研究的深入和相应临床应用的开展，患者也从临床获益。（剩余15950字）