身体质量指数和血脂对良性前列腺增生患者前列腺体积的影响

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Effects of body mass index and serum lipid levels on prostate volume in patients with benign prostatic hyperplasia

PANG Aibo LYU Jungang LING Cunbao ZHANG Tongshuo ZHANG Chunyan TIAN Yaping1

ABSTRACT：Objective To explore the correlation between body mass index （BMI） and lipid indexes with prostate volume in patients with benign prostatic hyperplasia （BPH） so as to provide reference for the clinical prevention of this disease.Methods Clinical data of 578 patients admitted to the Department of Urology of Chinese PLA General Hospital during Jan.2014 and Dec.2022 were collected.The patients underwent initial prostate puncture biopsy or prostatectomy and BPH was confirmed pathologically.The patients＇ age，time of onset of the disease，BMI，past medical history and biochemical indexes were analyzed.According to the total prostate volume （TPV） grading，the patients were divided into TPV＞75 mL and TPV≤75 mL groups.The general data of the two groups were compared，and predictors of TPV were determined with linear regression analysis.The samples were stratified with BMI to observe the differences in the effects of apolipoprotein B （ApoB） on TPV.Results There were 215 cases in the TPV＞75 mL group and 363 cases in the TPV≤75 mL group.The levels of BMI，triglyceride （TG），total cholesterol （TC），low-density lipoprotein cholesterol （LDL-C），and apolipoprotein B （ApoB） were higher in the TPV＞75 mL group （P＜0.01）.Multivariate linear regression analysis showed that age （β=0.60 P=0.003），BMI （β=2.000，P＜0.001），ApoB （β=23.79 P＜0.001） and TPV had a significant positive linear correlation；after adjusting for the confounders of age and BMI，ApoB was not linearly correlated with TPV in BPH population with BMI＜24 （P＞0.05），and ApoB predicted prostate volume growth in overweight and obese BPH population respectively （β=26.41 P=0.011；β=47.60 P=0.017）.Conclusion Age，ApoB and BMI can be used as predictors of volume growth in BPH patients，which can help further research on the pathogenesis and progression of BPH.

KEY WORDS：benign prostatic hyperplasia；prostate volume；body mass index；apolipoprotein B

摘要：目的 探讨良性前列腺增生（BPH）患者身体质量指数（BMI）和血脂水平与前列腺体积的相关性，为临床防治BPH提供参考。（剩余10531字）