青年（18~40岁）非透明细胞型肾恶性肿瘤患者的临床病理特点及预后

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（北京大学第三医院：1.泌尿外科，2.病理科，北京 100191）

Clinicopathological features and prognosis of non-clear cell renal cell carcinoma in young patients aged 18-40 years

TANG Shiying1，XUE Zixuan1，DONG Jinghan1，QIU Min1，TIAN Xiaojun1，LU Min2，ZHANG Shudong1，MA Lulin1

（1.Department of Urology，2.Department of Pathology，Peking University Third Hospital，Beijing 100191，China）

ABSTRACT：Objective To summarize the clinicopathological features and prognosis of young patients （18-40 years old） with non-clear cell renal cell carcinoma （nccRCC） treated in a single center to provide reference for the diagnosis and treatment of similar patients.Methods Clinical data of 113 nccRCC patients treated during Jan. 2012 and Aug. 2022 were retrospectively analyzed， including 57 males （50.4%） and 56 females （49.6%）. The average age of onset was （31.6±5.8）years. Among all patients， 57 had lesions （50.4%） on the left side， and 56 （49.6%） on the right side. Young patients undergoing renal cancer surgery accounted for approximately 12.4% of the total number of renal cancer patients undergoing surgery， and nccRCC accounted for 34.8% of the total number of cases. Results Minimally invasive surgery （laparoscopic or robot-assisted） was performed in 102 cases （90.3%）， and open surgery in 11 cases （9.7%）. Fifty-five cases （48.7%） underwent partial nephrectomy and 58 （51.3%） radical nephrectomy. Among them， 11 patients （9.7%） developed tumor thrombi. All surgeries were successful with no serious complications. The pathological types included 32 cases （28.3%） of chromophobe renal cell carcinoma， 25 cases （22.1%） of MiT family translocation renal cell carcinoma， and 20 cases （17.7%） of papillary renal cell carcinoma. The total proportion of the three pathological subtypes reached 68.1%. After 46 （2-115） months of follow-up， 8 cases

（7.8%，8/102） developed tumor metastasis and 2 died.Conclusion The nccRCC is rare in young patients. The major pathological type is chromophobe， and the major treatment method is minimally invasive surgery. Most pathological types have good long-term prognosis， while patients with tumor thrombi have a high risk of metastasis and poor prognosis.

KEY WORDS：youth；non-clear cell renal cell carcinoma；pathological types；chromophobe renal cell carcinoma;minimally invasive surgery

摘要：目的 分析总结单中心青年（18～40岁）非透明细胞型肾恶性肿瘤手术患者的临床、病理特征及预后，为同类患者的诊治提供参考。（剩余8962字）