铜调节的细胞死亡相关基因与前列腺癌关系分析

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（河南中医药大学第一附属医院泌尿外科一区，河南郑州 450003）

Analysis of the association between copper death-related genes and prostate cancer

LI Wei，CHENG Feng，ZHU Junlei，WANG Suogang

（The First Urology Ward，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450003，China）

ABSTRACT：

Objective To analyze the association between copper death-related genes and prognosis of prostate cancer and immune cell infiltration based on the cancer genome atlas （TCGA）.Methods The mRNA transcriptome data of all prostate cancer patients were downloaded from TCGA，including 501 prostate cancer tissues and 52 normal tissues.The expression matrix of copper death-related genes was extracted with R software.Differential analysis and multivariate regression analysis were conducted to screen out the prognostic genes，which were then analyzed to explore the correlation between prognosis-related genes and immune cells.Results GCSH gene was significantly correlated with the prognosis of prostate cancer，and significantly

correlated with dendritic cells，CD8+ T cells and plasma cells （P<0.05）.Conclusion GCSH gene plays an important role in the occurrence and development of prostate cancer，and may become a prognostic marker of the disease.

KEY WORDS：prostate cancer；copper-related cell death；

tumor microenvironment；glycine cleavage system protein H；cancer genome atlas；marker

摘要：目的 基于美国癌症肿瘤基因图谱（the cancer genome atlas，TCGA）数据库分析铜调节的细胞死亡相关基因与前列腺癌患者预后和免疫细胞浸润的关系。（剩余6569字）