某三甲医院1548株铜绿假单胞菌临床分布、耐药性及流行病学分析

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中图分类号：R978.1 文献标志码：A文章编号：1001-8751（2025）05-0333-06

Analysis of Clinical Distribution，Drug Resistance and Epidemiology of 1 548 StrainsofPseudomonasaeruginosa ina TertiaryHospital

Zheng Yuan-ming，Jiang Ran-ran， Zhou Jie（Dalian Friendship Hospital，Dalian 116001）

Abstract： Objective A theoretical basis for the clinical treatment of Pseudomonas aeruginosa（PA） infection and the prudent use of antibacterial drugs was established by analyzing the source and clinical distribution of PA infections at Dalian Friendship Hospital over the previous seven years，as well as the resistance of eleven commonclinical antibacterialdrugs.Methods Retrospective analysis of 1548 strains ofPAat Dalian Friendship Hospital from January 2017to June 2024，analyzed the drug susceptibilityresults using Whonet 5.6 software，and a chisquare test was performed with Spss26 software.Results Among 1 548 strains of PA，1 062 strains （68.60% ） mainly came from sputum.These strains were mainly distributed in the Intensive Care Unit（614 strains， 39.66% ） The majority of the patients were elderly males （70.56%） and over75years old （69.01%） .Levofloxacin （31.65%） and meropenem （31.42%） had the highest resistance rates，while cefepime（ （14.94%） andamikacin （12.50%） had the lowest.The resistance rates of carbapenem-resistant P. aeruginosa （456 strains， 29.46% ）and fluquinolone-resistant P.aeruginosa （654 strains， 42.25% ）were more than twice those of the total bacterial group.Conclusion The patients infected with PA are mainly elderly males，and the infections are more common in summer; the resistance rates to meropenemand levofloxacin were the highest.For multi-drug resistant bacteria，clinical combined therapy is recommended.Itis helpfulto clarifytheepidemiologicalcharacteristicsof Pseudomonas aeruginosa in order to take effective prevention and control measures in clinical practice.

Key words：Pseudomonas aeruginosa;clinical distribution;drug resistance;antimicrobial agents； multi-drug resistance； epidemiology

铜绿假单胞菌（Pseudomonasaeruginosa，PA）为非发酵性革兰阴性菌，是一种常见院内感染的条件致病菌。（剩余6933字）