乌帕替尼缓释片致血红蛋白降低1例

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【中图分类号】R975 【文献标识码】A

【Abstract】This article reports a case of a patient with Crohn's disease who had 1 to 2 loose stools per day， occasionally with a small amount of bloody stool. Despite treatment with multiple drugs in the past， the disease was still poorly controlled.The patient was switched to upadacitinib extended-release tablets 45mg once daily for oral administration. The patient's hemoglobin level decreased continuously， with the lowest value of 68g⋅L-1 .Afterevaluation，it was determined that the decrease in hemoglobin was very likely related to upadacitinib extended-release tablets. The upadacitinib was discontinued，and vedolizumab was used for continued treatment. Symptomatic treatment was also given，and the patient's hemoglobin level gradually recovered.This article analyzes the clinical characteristics of upadacitinib-induced hemoglobin reduction in this case and the treatment plan optimization process， to provide a reference for safe clinical medication.

【Keywords】Upadacitinib; Crohn's disease; Decreased hemoglobin; Adverse drug reactions

乌帕替尼是一种Janus 激酶（Januskinase，JAK）抑制剂。（剩余9807字）