重组人源胶原蛋白敷料联合普罗雌烯软膏对萎缩性阴道炎患者症状及阴道微生态的影响

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【中图分类号】R711.31 【文献标识码】A

【Abstract】 Objective To explore the influence of combination of recombinant human collagen dressing and promestriene ointment on symptoms and vaginal microecology in patients with atrophic vaginitis.Methods The data of patients with atrophic vaginitis admitted to the General Hospital of the People's Liberation Army were retrospectively collected from April 2017 to April 2024.According to treatment methods，the enrolled patients were divided into a study group （recombinant human collagen dressing combined with promestriene ointment for 7 days）and a control group （promestriene ointment for7days）.The eficacy，symptomdisappearance time，vaginal microecologyand adverse reactions were compared between groups，and recurrence rate of atrophic vaginitis within1 month was observed. Results A total of 150 patients were screened and included，77 in the study group and 73 in the control group. After treatment，the total therapeutic effcacy in the study group was higher than that in the control group （ 89.61% Vs. 76.71% P<0.05 ）. The disappearance durations of abnormal leucorrhea， vulva pruritus and vulva burning pain in the study group were significantly shorter compared with those in the control group （all P<0.05 ）. The vaginal ΔpH value in the study group was lower， while the positive rate of Lactobacillus and proportions of vaginal flora density grade I1-II and diversity grade II-II were higher compared to the control group （all P<0.05 ）. During treatment，no significant diference was exhibited in the total incidence rate of adverse reactions between the two groups （P>0.05） ）. The recurrence rate was lower in the study group than that in the control group within 1 month of follow-up （P<0.05） . Conclusion Recombinant human collagen dressing combined with promestriene ointment is more effective than promestriene ointment alone in improving the effcacy of patients with atrophic vaginitis，and can better shorten the disappearance durations ofsymptoms such asabnormal leucorrhea，vulva pruritus and vulva burning pain， correct the disorder of vaginal microecology，and reduce the short-term recurrence rate of vaginitis，and offer good safety.

【KeyWords】Recombinant human collagen; Promestriene; Atrophic vaginitis; Efficacy; Vaginal microecology

萎缩性阴道炎是绝经后女性常见的疾病，其发病与雌激素水平下降引发的阴道黏膜萎缩变薄、糖原合成减少及酸碱度（pH）值升高密切相关，可导致乳酸杆菌减少而致病菌过度增殖，形成以菌群失调为核心的病理改变。（剩余11269字）