聚乙二醇化重组人粒细胞刺激因子注射液致急性肾损伤1例

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【关键词】聚乙二醇化重组人粒细胞刺激因子注射液；急性肾损伤；药品不良反应【中图分类号】 【文献标识码】A

【Abstract】A 58-year-old female patient with breast cancer received treatment with pegylated recombinant human granulocyte colony-stimulating factor （PEG-rhG-CSF） injection after adjuvant chemotherapy. The serum creatinine level of the patient gradually increased from the normal baseline value to 199.3μmol⋅L-1 . The patient was diagnosed as acute kidney injury （AKI），after stopping the medication and providing symptomatic treatment， the patient's renal function gradually improved.The patient completed subsequent chemotherapy as planned without reusing PEG-rhG-CSF injection，and other medications and dosages remained unchanged. Renal function remained stable during follow-up. Naranjo’s Assessment Scale was used to evaluate the association between PEG-rhG-CSF injectionand AKI， the result was "probable." There are few reports of AKI occuring with PEG-rhG-CSF injection，and this case provides evidence for clinical safe medication.

【Keywords】 Pegylated recombinant human granulocyte colony-stimulating factor; Acute kidney injury; Adverse drug reaction

中性粒细胞减少症是化疗常见的血液学毒性[1-2]，可能造成患者化疗药物剂量降低、化疗时间延迟甚至终止化疗，还可能增加感染及死亡风险，对患者预后造成不良影响[3-4]。（剩余7203字）