基于真实世界研究的活络消痛胶囊治疗神经根型颈椎病疗效观察

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【中图分类号】R969.4 【文献标识码】A

【Abstract】 Objective To compare the early efficacy and safety of Huoluo Xiaotong capsules and Jingtong granules in treating cervical spondylosis radiculopathy （CSR）. Methods A real-world study was conducted among CSR patients who visited three tertiary-grade-A hospitals in Changsha between January 2024 and February 2025.Patients were divided into a control group （Jingtong granules， 4g; ，po， tid） and an observation group （Huoluo Xiaotong capsules， po， tid）; both groups were treated for 2 weeks. Baseline characteristics were balanced with inverse probability of treatment weighting （IPTW）. Numeric rating scale （NRS） scores， overal response rates，and traditional Chinese medicine（TCM） symptom scores were compared at baseline，1 week，and 2 week. Results A total of 120 patients were ultimately included，with 30 in the control group and 90 in the observation group.After IPTW adjustment，at1 week of treatment， the clinical efficacy rate of observation group （98.85% ）were significantly exceeded that of control group （80.14%） （P<0.001） ; at 2 weeks，the clinical efficacy rate of the two groups were both 100.00% .NRS and TCM syndrome scores showed no intergroup differences at baseline or 1 week （P>0.05） ），at2weeks，the observation group demonstrated significantly lower NRS and TCM syndrome scores versus controls （P<0.001） ） No adverse reactions occurred in either group. Conclusion Huoluo Xiaotong capsules demonstrate favorable short-term efficacy and safety in CSR， significantly alleviating pain and improving TCM symptoms within 2 weeks.High-quality randomized controlled trials are warranted to confirm these findings.

【Keywords 】Cervical spondylosis radiculopathy; Huoluo Xiaotong capsules; Real-world study; Efficacy evaluation

神经根型颈椎病（cervicalspondylosisradiculopathy，CSR）是颈椎病常见类型之一，多因颈椎间盘退变、骨质增生或椎间关节紊乱，刺激或压迫神经根所致[1-3]。（剩余10965字）