Lefamulin：一种新型人用截短侧耳素类抗菌药物的临床药学研究

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摘要：Lefamulin是全球首个静脉和口服剂型的人用截短侧耳素类抗菌药物，具有独特的作用机制，与其他临床用抗菌药物不易产生交叉耐药性。对社区获得性肺炎、皮肤软组织感染以及性传播疾病的常见病原体有良好的抗菌活性。本文就lefamulin的作用机制、耐药机制、抗菌活性以及临床使用等方面进行综述。

关键词：截短侧耳素；lefamulin；抗菌活性；临床药学

中国分类号：R978.1        文献标志码：A

Clinical pharmacology of lefamulin-a new pleuromutilin class

of antibiotics for human use

Xue Feng1， Ma Xu-zhu2 and Zheng Bo1

（1 Institute of Clinical Pharmacology， Peking University First Hospital， Beijing 100034;

2 General Internal Medicine， Beijing Tsinghua Changgung Hospital， Tsinghua University， Beijing 102218）

Abstract    Lefamulin， the first semisynthetic pleuromutilin antibacterial for oral and intravenous administration in patients， has a unique mechanism against bacteria and does not show cross-resistance with other antimicrobials. In vitro studies have demonstrated that lefamulin has potent activity against a variety of bacteria that cause community-acquired pneumonia， skin and soft tissue infections and sexually transmitted diseases. This article reviews the mechanism， drug resistance， antibacterial activity， and clinical use of lefamulin.

Key words    Pleuromutilin; Lefamulin; Antimicrobial activity; Clinical pharmacology

截短侧耳素类抗菌药物早在20世纪70年代就被作为兽用抗菌药物，近年来将其作为人用抗菌药的研究趋热。（剩余6475字）