冠心病抗炎治疗的临床研究进展

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【摘要】炎症是导致冠心病发生和发展的重要因素，抗炎治疗成为进一步降低冠心病残余风险的希望，然而目前临床上并无规范的抗炎治疗策略。近年来多项大规模的随机、双盲对照试验为寻找冠心病的抗炎治疗策略指引了方向。现结合近年来循证证据就冠心病抗炎治疗的进展做一综述。

【关键词】冠心病；抗炎治疗；残余炎症风险

【DOI】10.16806/j.cnki.issn.1004-3934.2024.03.017

Clinical Research Progress in Anti-Inflammatory Therapy of Coronary Heart Disease

ZHUANG Wenwen，DU Mingliang，HUI Hui，ZHENG Xiaoqun

（Department of Coronary Heart Disease，Dalian Central Hospital，Dalian 116032，Liaoning，China）

【Abstract】Inflammation can lead to the development of coronary heart disease（CHD），and anti-inflammatory therapy has become the hope to further reduce the residual risk of CHD.However，there is no standard anti-inflammatory therapy strategy in clinical practice.In recent years，a number of large-scale randomized，double-blind，placebo-controlled clinical studies have guided the search for anti-inflammatory therapy for CHD.This article reviews the progress of anti-inflammatory therapy for CHD based on evidence-based research in recent years.

【Keywords】Coronary heart disease；Anti-inflammatory treatment；Residual inflammation risk

冠心病指冠状动脉粥样硬化引起管腔狭窄或闭塞，导致心肌缺血、缺氧或坏死，大量的循证证据已证实胆固醇浓度升高（主要由低密度脂蛋白颗粒转运）会促进动脉粥样硬化（atherosclerosis，AS）的发生和发展，降低胆固醇水平能延缓斑块进展，降低不良心血管事件的发生率，在冠心病的二级预防中起到基石作用［1］。（剩余13095字）