SIRT1介导的信号通路在阿霉素诱导心脏毒性中的作用机制

【摘要】沉默信息调节因子1（SIRT1）通过介导多种信号通路参与调节氧化应激、线粒体功能、细胞凋亡、炎症反应、内质网应激、纤维化等病理生理过程，在阿霉素诱导的心脏毒性中发挥保护作用。现总结SIRT1介导的信号通路在阿霉素诱导心脏毒性中的作用机制。

【关键词】沉默信息调节因子1；信号通路；阿霉素；心脏毒性

【DOI】10.16806/j.cnki.issn.1004-3934.2024.03.015

The Mechanisms of SIRT1-Mediated Signal Pathway in Doxorubicin-Induced Cardiotoxicity

LI Dengke，ZHANG Wei，HUANG Congxin

（Department of Cardiology，Renmin Hospital of Wuhan University，Cardiovascular Research Institute，Wuhan University，Hubei Key Laboratory of Cardiology，Wuhan 430060，Hubei，China）

【Abstract】Silence information regulator 1（SIRT1） plays a protective role in doxorubicin-induced cardiotoxicity by mediating a variety of signaling pathways to participate in the regulation of oxidative stress，mitochondrial function，apoptosis，inflammatory response，endoplasmic reticulum stress，fibrosis and other pathological and physiological processes.This review summarizes the mechanisms of SIRT1-mediated signaling pathways in doxorubicin-induced cardiotoxicity.

【Keywords】Silence information regulator 1；Signal pathway；Doxorubicin；Cardiotoxicity

阿霉素（doxorubicin，DOX）是一种广泛应用的化疗药物，用于治疗各种类型的癌症，然而DOX的剂量依赖性心脏毒性极大地限制了其临床应用，最终导致不可逆的退行性心脏病和充血性心力衰竭［1］。（剩余11203字）