经皮去肾神经术：最新证据与患者筛选

【摘要】尽管有许多药物和非药物治疗可降低血压，但难治性高血压仍是一个重要的健康问题。经皮去肾神经术（RDN）已成为有发展前景、临床证据最多的用于改善血压、提高血压控制率的器械治疗方法。现总结目前RDN治疗高血压的机制，同时总结关于RDN的多项随机假手术对照的临床研究和优化患者选择。

【关键词】高血压；交感神经系统；去肾神经术

【DOI】10.16806/j.cnki.issn.1004-3934.2024.03.005

Percutaneous Renal Denervation：Latest Evidence and Patient Selection

LI Yue，LU Chengzhi

（Tianjin First Central Hospital，Tianjin 300000，China）

【Abstract】Despite the existence of numerous pharmacological and non-pharmacological interventions for lowering blood pressure，refractory hypertension persists as a significant health concern.Renal denervation（RDN） has become a promising and clinically proven instrument therapy method for improving blood pressure and increasing blood pressure control.This review summarizes the current understanding of the mechanisms behind RDN in treating hypertension and provides an overview of several randomized sham-controlled clinical studies on RDN，as well as optimization of patient selection.

【Keywords】Hypertension；Sympathetic nervous system；Renal denervation

多年来，交感神经系统与心血管疾病之间的关系早已为人所知，相关研究［1-3］探讨了交感神经系统活性增加与难治性高血压之间的联系。（剩余13966字）