氟喹诺酮类药物增加主动脉瘤和夹层风险的研究进展

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【摘要】主动脉瘤(AA)和主动脉夹层(AD)是威胁生命健康的主要疾病。氟喹诺酮类抗生素(FQ)具有重要的临床用途和广泛的抗菌谱。FQ可导致主动脉血管破裂风险增加。FQ诱导AA/AD的确切机制目前尚不十分清楚。现讨论FQ与AA/AD之间相关性的最新研究进展。

【关键词】主动脉瘤;主动脉夹层;氟喹诺酮类药物

【DOI】10.16806/j.cnki.issn.1004-3934.2023.02.013

【Abstract】Aortic aneurysm(AA) and aortic dissection (AD) are major life-threatening diseases around the world.Fluoroquinolones (FQ) remain one of the most important kind of antibiotics and have a wider clinical use and broad antibacterial spectrum.FQ was warned about an increased risk of ruptures in the aorta blood vessel in certain patients.The exact mechanism of FQ-induced AA/AD remains unclear.This review aims to the latest research progress of the alarming association between FQ and AA/AD.

【Key words】Aortic aneurysm; Aortic dissection; Fluoroquinolones

氟喹诺酮类药物(fluoroquinolones,FQ)是临床工作中最常用的抗生素之一,研究[1-3]显示其可能与急性主动脉瘤(aortic aneurysm,AA)和主动脉夹层(aortic dissection,AD)有关,FQ的使用可增加AA/AD的发病风险。(剩余9240字)

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