合理组装不同表面功能化碳点以增强近红外肿瘤光热治疗效果

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Abstract： Carbon dots （CDs） have emerged as promising photothermal agentsfornear-infrared （NiR）-mediated tumor therapydue to theirexcellent biocompatibility tunable optical properties.However， it isstill unclear howto preciselycontrol theirassembly behavior toenhance NiRabsorption photothermalconversionefficiency.Inthiswork，wepresentahyperassembled electron donor/acceptor CDs complex （S-d/a-CDs）， constructed byintegrating electron-donating CDs （d-CDs）with electron-withdrawing CDs （a-CDs）.This configuration significantly enhances the NiR absorption capacity S-d/a-CDs. Under 740nm laser irradiation， S-d/a-CDsachieve a remarkable photothermal conversion efficiency （PTCE） 65.8% . S-d/a-CDs exhibit negligible cytotoxicity effective tumor accumulation capacity throughintravenous administration，enabling complete tumor eliminationafter NIR laseriradiation.Toour knowledge，this study is thefirstto exploit synergistic assembles two types CDs for photo-physical propertyengineering， establishing a groundbreaking paradigm for the development advanced NIR-triggered photothermal materials.

KeyWords：Carbon dots；Photothermal therapy;Hydrogen bond;Assemble;Donor/acceptor

摘要：碳点（CDs）因其优异的生物相容性和可调的光学特性，已成为近红外（NIR）介导的肿瘤治疗中极具前景的光热剂。（剩余20361字）