锌稳态在前列腺疾病中的作用及潜在机制

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【中图分类号】 R697+.3 ； R737.25 【文献标识码】A

The role of zinc homeostasis in prostate diseases and potential mechanisms

HAN Yutong1²2， FAN Jiuming1.2， WANG Tiankun1：2， QI Zihao1²2， ZHANG Yuanyuan²， HOU Junqing³4

1. School of Clinical Medicine，Henan University，Kaifeng 4754oo，HenanProvince， China

2.Center for Evidence-Based and Translational Medicine，Zhongnan Hospitalof Wuhan University，Wuhan 430071， China

3.DepartmentofUrology，Kaifeng155Hospital，ChinaRongTongMedicalHealthcareGroupCo.Ltd，Kaifeng47540o，Henan Province， China

4.Henan Engineering Research Center of Prostate Disease Preventionand Diagnosis， Kaifeng475400，Henan Province，China

Corresponding authors： HOU Junqing， Email： hjq0418@sina.com; ZHANG Yuanyuan， Email： zhangyy_ph@163.com

【Abstract】 Zinc is an essential trace element in the human body， participating in various critical physiological functions and being highly concentrated in the prostate gland. Studies have shown that prostate diseases might be associated with zinc imbalance.Investigating the regulatory mechanisms and dynamic patterns of zinc homeostasis in prostate diseases holds significant importance for exploring the pathogenesis， progression mechanisms，and zinc homeostasis-based prevention and treatment strategies for prostate disorders.Building on a synthesis of previous evidence，this review elaborates on the maintenance processes and key regulatory factors of zinc homeostasis in the human body，and provides an in-depth analysis of zinc's role in the development and progression of prostate diseases，along with potential underlying biological mechanisms.

【Keywords】 Zinc; Zinc Homeostasis; Prostatic diseases; Prostate cancer; Benign prostatic hyperplasia

前列腺作为男性生殖器附件中最大的非成对实质性器官，其组织结构异常可引发前列腺炎、良性前列腺增生（benign prostatic hyperplasia，BPH）及前列腺癌（prostatecancer，PCa）等良、恶性疾病的发生。（剩余24461字）